Environmental cues regulate epigenetic reprogramming of airway-resident memory CD8+ T cells.
Identifieur interne : 000513 ( Main/Exploration ); précédent : 000512; suivant : 000514Environmental cues regulate epigenetic reprogramming of airway-resident memory CD8+ T cells.
Auteurs : Sarah L. Hayward [États-Unis] ; Christopher D. Scharer [États-Unis] ; Emily K. Cartwright [États-Unis] ; Shiki Takamura [Japon] ; Zheng-Rong Tiger Li [États-Unis] ; Jeremy M. Boss [États-Unis] ; Jacob E. Kohlmeier [États-Unis]Source :
- Nature immunology [ 1529-2916 ] ; 2020.
Descripteurs français
- KwdFr :
- Animaux, Apoptose (immunologie), Femelle, Infections à Orthomyxoviridae (anatomopathologie), Infections à Orthomyxoviridae (génétique), Infections à Orthomyxoviridae (immunologie), Lymphocytes T CD8+ (cytologie), Lymphocytes T CD8+ (immunologie), Microenvironnement cellulaire (génétique), Microenvironnement cellulaire (immunologie), Mâle, Mémoire immunologique (génétique), Poumon (cytologie), Poumon (immunologie), Reprogrammation cellulaire (génétique), Reprogrammation cellulaire (immunologie), Souris, Souris de lignée C57BL, Survie cellulaire (génétique), Survie cellulaire (immunologie), Épigenèse génétique (immunologie).
- MESH :
- anatomopathologie : Infections à Orthomyxoviridae.
- cytologie : Lymphocytes T CD8+, Poumon.
- génétique : Infections à Orthomyxoviridae, Microenvironnement cellulaire, Mémoire immunologique, Reprogrammation cellulaire, Survie cellulaire.
- immunologie : Apoptose, Infections à Orthomyxoviridae, Lymphocytes T CD8+, Microenvironnement cellulaire, Poumon, Reprogrammation cellulaire, Survie cellulaire, Épigenèse génétique.
- Animaux, Femelle, Mâle, Souris, Souris de lignée C57BL.
English descriptors
- KwdEn :
- Animals, Apoptosis (immunology), CD8-Positive T-Lymphocytes (cytology), CD8-Positive T-Lymphocytes (immunology), Cell Survival (genetics), Cell Survival (immunology), Cellular Microenvironment (genetics), Cellular Microenvironment (immunology), Cellular Reprogramming (genetics), Cellular Reprogramming (immunology), Epigenesis, Genetic (immunology), Female, Immunologic Memory (genetics), Lung (cytology), Lung (immunology), Male, Mice, Mice, Inbred C57BL, Orthomyxoviridae Infections (genetics), Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (pathology).
- MESH :
- cytology : CD8-Positive T-Lymphocytes, Lung.
- genetics : Cell Survival, Cellular Microenvironment, Cellular Reprogramming, Immunologic Memory, Orthomyxoviridae Infections.
- immunology : Apoptosis, CD8-Positive T-Lymphocytes, Cell Survival, Cellular Microenvironment, Cellular Reprogramming, Epigenesis, Genetic, Lung, Orthomyxoviridae Infections.
- pathology : Orthomyxoviridae Infections.
- Animals, Female, Male, Mice, Mice, Inbred C57BL.
Abstract
Tissue-resident memory T cells (TRM cells) are critical for cellular immunity to respiratory pathogens and reside in both the airways and the interstitium. In the present study, we found that the airway environment drove transcriptional and epigenetic changes that specifically regulated the cytolytic functions of airway TRM cells and promoted apoptosis due to amino acid starvation and activation of the integrated stress response. Comparison of airway TRM cells and splenic effector-memory T cells transferred into the airways indicated that the environment was necessary to activate these pathways, but did not induce TRM cell lineage reprogramming. Importantly, activation of the integrated stress response was reversed in airway TRM cells placed in a nutrient-rich environment. Our data defined the genetic programs of distinct lung TRM cell populations and show that local environmental cues altered airway TRM cells to limit cytolytic function and promote cell death, which ultimately leads to fewer TRM cells in the lung.
DOI: 10.1038/s41590-019-0584-x
PubMed: 31953534
Affiliations:
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Kohlmeier</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA. jkohlmeier@emory.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author></analytic><series><title level="j">Nature immunology</title><idno type="eISSN">1529-2916</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Apoptosis (immunology)</term><term>CD8-Positive T-Lymphocytes (cytology)</term><term>CD8-Positive T-Lymphocytes (immunology)</term><term>Cell Survival (genetics)</term><term>Cell Survival (immunology)</term><term>Cellular Microenvironment (genetics)</term><term>Cellular Microenvironment (immunology)</term><term>Cellular Reprogramming (genetics)</term><term>Cellular Reprogramming (immunology)</term><term>Epigenesis, Genetic (immunology)</term><term>Female</term><term>Immunologic Memory (genetics)</term><term>Lung (cytology)</term><term>Lung (immunology)</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Orthomyxoviridae Infections (genetics)</term><term>Orthomyxoviridae Infections (immunology)</term><term>Orthomyxoviridae Infections (pathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Apoptose (immunologie)</term><term>Femelle</term><term>Infections à Orthomyxoviridae (anatomopathologie)</term><term>Infections à Orthomyxoviridae (génétique)</term><term>Infections à Orthomyxoviridae (immunologie)</term><term>Lymphocytes T CD8+ (cytologie)</term><term>Lymphocytes T CD8+ (immunologie)</term><term>Microenvironnement cellulaire (génétique)</term><term>Microenvironnement cellulaire (immunologie)</term><term>Mâle</term><term>Mémoire immunologique (génétique)</term><term>Poumon (cytologie)</term><term>Poumon (immunologie)</term><term>Reprogrammation cellulaire (génétique)</term><term>Reprogrammation cellulaire (immunologie)</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Survie cellulaire (génétique)</term><term>Survie cellulaire (immunologie)</term><term>Épigenèse génétique (immunologie)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections à Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Lymphocytes T CD8+</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>CD8-Positive T-Lymphocytes</term><term>Lung</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cell Survival</term><term>Cellular Microenvironment</term><term>Cellular Reprogramming</term><term>Immunologic Memory</term><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Infections à Orthomyxoviridae</term><term>Microenvironnement cellulaire</term><term>Mémoire immunologique</term><term>Reprogrammation cellulaire</term><term>Survie cellulaire</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Apoptose</term><term>Infections à Orthomyxoviridae</term><term>Lymphocytes T CD8+</term><term>Microenvironnement cellulaire</term><term>Poumon</term><term>Reprogrammation cellulaire</term><term>Survie cellulaire</term><term>Épigenèse génétique</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Apoptosis</term><term>CD8-Positive T-Lymphocytes</term><term>Cell Survival</term><term>Cellular Microenvironment</term><term>Cellular Reprogramming</term><term>Epigenesis, Genetic</term><term>Lung</term><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Mâle</term><term>Souris</term><term>Souris de lignée C57BL</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Tissue-resident memory T cells (T<sub>RM</sub> cells) are critical for cellular immunity to respiratory pathogens and reside in both the airways and the interstitium. In the present study, we found that the airway environment drove transcriptional and epigenetic changes that specifically regulated the cytolytic functions of airway T<sub>RM</sub> cells and promoted apoptosis due to amino acid starvation and activation of the integrated stress response. Comparison of airway T<sub>RM</sub> cells and splenic effector-memory T cells transferred into the airways indicated that the environment was necessary to activate these pathways, but did not induce T<sub>RM</sub> cell lineage reprogramming. Importantly, activation of the integrated stress response was reversed in airway T<sub>RM</sub> cells placed in a nutrient-rich environment. Our data defined the genetic programs of distinct lung T<sub>RM</sub> cell populations and show that local environmental cues altered airway T<sub>RM</sub> cells to limit cytolytic function and promote cell death, which ultimately leads to fewer T<sub>RM</sub> cells in the lung.</div></front></TEI><affiliations><list><country><li>Japon</li><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li></region></list><tree><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Hayward, Sarah L" sort="Hayward, Sarah L" uniqKey="Hayward S" first="Sarah L" last="Hayward">Sarah L. Hayward</name></region><name sortKey="Boss, Jeremy M" sort="Boss, Jeremy M" uniqKey="Boss J" first="Jeremy M" last="Boss">Jeremy M. Boss</name><name sortKey="Cartwright, Emily K" sort="Cartwright, Emily K" uniqKey="Cartwright E" first="Emily K" last="Cartwright">Emily K. Cartwright</name><name sortKey="Kohlmeier, Jacob E" sort="Kohlmeier, Jacob E" uniqKey="Kohlmeier J" first="Jacob E" last="Kohlmeier">Jacob E. Kohlmeier</name><name sortKey="Li, Zheng Rong Tiger" sort="Li, Zheng Rong Tiger" uniqKey="Li Z" first="Zheng-Rong Tiger" last="Li">Zheng-Rong Tiger Li</name><name sortKey="Scharer, Christopher D" sort="Scharer, Christopher D" uniqKey="Scharer C" first="Christopher D" last="Scharer">Christopher D. Scharer</name></country><country name="Japon"><noRegion><name sortKey="Takamura, Shiki" sort="Takamura, Shiki" uniqKey="Takamura S" first="Shiki" last="Takamura">Shiki Takamura</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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